Arimidex is a very new drug developed for the treatment of advanced breast cancer in women. Specifically, Arimidex is the first in a new class of third-generation selective oral aromatase inhibitors. It acts by blocking the enzyme aromatase, subsequently blocking the production of estrogen. Since many forms of breast cancer cells are stimulated by estrogen, it is hoped that by reducing amounts of estrogen in the body the progression of such a disease can be halted.

How it works
Stanozolol 5 mg. per tab. DHT derivative. Low androgenic steroid with little or no aromatization.
Women, however, often prefer the oral Winstrol This, by all means, makes sense since female athletes have a distinetly lower daily requirement of stanozolol, usually 10-16 mg/day. Thus the daily quantity of tablets is reduced to 5-8 so that gastrointestinal pain and inereased liver values occur very rarely. Another reason for the oral intake in women is that the dosage to be taken can be divided into equal doses. This has the advantage that unlike the 50 mg injections-it does not lead to a significant increase in the androgens and thus the androgenic-caused side effects (virilization symptoms) can be reduced.
Athletes who have opted for the oral administration of Winstrol usually take their daily dose in two equal amounts mornings and evenings with some liquid during their meals. This assures a good absorption of the substance and, at the same time, minimizes possible gastrointestinal pain.

Stanozolol tablets are manufactured in the 5 mg version by Body Research. Even on the European black market these tablets are found only on rare occasions. Usually the Spanish Winstrol by Zambon show up. The American Winstrol tablets by Winthrop and Upjohn also contain 2 mg stanozolol tablets.
Winstrol depot is very popular anabolic steroid and is a derivative of DHT. It is a relatively low androgenic steroid which does not seem to aromatize. It can be toxic to the liver in excessive dosages. Very few user report water retention or any other side effects. It is a popular all purpose steroid; many stack with Primobolan for cutting, others stack it with testosterone for size and strength gains. Users report that the muscle gains they make are solid, they are well retained after the drug use is discontinued. Athletes also find that the injectable version is far superior to the oral. Dosages range from 3-5 cc per week for men, 1-2 cc in women. Oral dosages are usually in the area of 16-30 mg per day for men, 4-8 mg for women.

Dosages
Considering the fact that the injectable Winstrol Depot is usually taken in a dosage of 50 mg/day or at least 50 mg every second day and when comparing this with the actual daily quantity of tablets taken by many athletes, our thesis is confirmed. Since, in the meantime, one would have to take at least 16-30 mg daily to obtain the quantity of the substance one receives when injecting. For two reasons, this, however, cannot be realized by must athletes.

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Description
Methyltestosterone is one of the oldest available oral steroids. It is quite androgenic, with minimal anabolic effects. For athletic purposes, methyltest is generally only used to stimulate aggression among power lifters and those looking to boost up their workouts. Methyltestosterone is an orally available form of the primary male androgen testosterone. Looking at the structure of this steroid, we see it is basically just testosterone with an added methyl group at the c-17 alpha position (a c-17 alpha alkylated substance). Alkylation such as this is necessary when administering testosterone (and other steroids) orally, as without it the liver will destroy most of the steroid during the "first pass". The resultant compound "methylated-testosterone" was among the first functional oral steroids to be produced. This field of research has consequently improved greatly over the years, and today methyltestosterone is quite crude in comparison to many of the other orals that were subsequently developed.

Methyltestosterone offers little except androgenic side effects. It is quite toxic, elevating liver enzymes and causing acne, gynecomastia, aggression and water retention quite easily. Were one to tolerate these side-effects, Methyltestosterone will offer little more than some slight strength gains.

The action of this steroid is somewhat androgenic, with a moderate anabolic effect. As is typically seen with 17 alpha methylation, the resulting steroid has lower anabolic activity than its parent testosterone. Additionally it is extremely estrogenic, another property that seems to be enhanced when this alteration is present (when the steroid is receptive to the aromatase enzyme). The problem seems to be its conversion to the more biologically active estrogen 17-alpha methylestradiol. 17-alpha methylation in fact slows aromatization, however the potent nature of 1 -methylestradiol more than compensates for this. Additionally it has a very short half-life in the body, so the drug needs to be administered several times daily if a consistent blood level is to be obtained. All of this heightens the ratio of side effects to muscle growth enough to make methyltestosterone a very inefficient muscle-building drug. In order to administer an effective amount of hormone, the user simply must deal with too many estrogenic side effects, including water retention and gynecomastia, which can be very troublesome with this steroid. One may choose to addition an anti-estrogen such as Nolvadex and/or Proviron to combat related side effects, which should effectively minimize their intensity enough to make a cycle tolerable. The powerful antiaromatase Arimidex is a notably more effective option when dealing with aromatizable steroids, as it shows great ability to stop the conversion of androgens to estrogens.

oxymetholone, a very potent oral androgen. This compound was first made available in 1960, by the international drug firm Syntex. Since oxymetholone is quite reliable in its ability to increase red blood cell production (and effect admittedly characteristic of nearly all anabolic/androgenic steroids), it showed particular promise in treating cases of severe anemia. For this purpose it turned out to be well suited, and was popular for quite some time. But recent years have brought fourth a number of new treatments, most notably the non-steroidal hormone Epogen (erythropoietin). This item is shown to have a much more direct effect on the red blood cell count, without the side effects of a strong androgen.
A steroid novice experimenting with oxymetholone is likely to gain 20 to 30 pounds of massive bulk, and it can often be accomplished in less than 6 weeks, with only one or two tablets per day. This steroid produces a lot of trouble with water retention, so let there be little doubt that much of this gain is simply bloat. But for the user this is often little consequence, feeling bigger and stronger on Anadrol than any steroid they are likely to cross. Although the smooth look that results from water retention is often not attractive, it can aid quite a bit to the level of size and strength gained. The muscle is fuller, will contract better and is provided a level of protection in the form of "lubrication" to the joints as some of this extra water is held into and around connective tissues. This will allow for more elasticity, and will hopefully decrease the chance for injury when lifting heavy. It should be noted however, that on the other hand the very rapid gain in mass might place too much stress on your connective tissues for this to compensate. The tearing of pectoral and biceps tissue is commonly associated with heavy lifting while massing up on heavy androgens. There is such a thing as gaining too fast. Pronounced estrogen trouble also puts the user at risk for developing gynecomastia. Individuals sensitive to the effects of estrogen, or looking to retain a more quality look, will therefore often add Nolvadex to each cycle.

It is important to note however, that this drug does not directly convert to estrogen in the body. Oxymetholone is a derivative of dihydrotestosterone, which gives it a structure that cannot be aromatized. As such, many have speculated as to what makes this hormone so troublesome in terms of estrogenic side effects. Some have suggested that it has progestational activity, similar to nandrolone, and is not actually estrogenic at all. Since the obvious side effects of both estrogens and progestins are very similar, this explanation might be a plausible one. However we do find medical studies looking at this possibility. One such tested the progestational activity; of various steroids including nandrolone, norethandrolone, methandrostenolone, testosterone and oxymetholone. It reported no significant progestational effect inherent in oxymetholone or methandrostenolone, slight activity with testosterone and strong progestational effect inherent in nandrolone and norethandrolone. With such findings it starts to seem much more likely that oxymetholone can intrinsically activate the estrogen receptor itself, similar to but more profoundly than the estrogenic androgen methandriol. Clearly if this is the case we can only combat the estrogenic side effects of oxymetholone with estrogen receptor antagonists such as Nolvadex or Clomid, and not with an aromatase inhibitor. The strong anti-aromatase compounds such as Cytadren and Arimidex would similarly prove to be totally useless with this steroid, as aromatase is uninvolved.


Testoviron Enanthate: 250 mg/ml 1 cc/amp. Testoviron depot is a long acting injectable testosterone that is widely used amongst athletes. It is currently the most popular testosterone ester available to athletes. Unlike cypionate, enanthate is manufactured by various companies all over the world. Ampules of Testoviron depot from Schering are probably the most popular although many others exist. Enanthate is a long acting testosterone similar to cypionate. Injections of Testoviron depot are taken once weekly, with a dosage of 200-600 mg being most common for athletes. It has very strong anabolic effects as well as strong androgenic side effects.
Gynocomastia and water retention are the most common side effects and should be watched for. Being an injectable testosterone, liver values are generally not elevated much by this product. It only needs to be administered once every 7 days as opposed to cypionate's weekly injections. This yields greater convenience and cost effectiveness. Effective dosages of Testoviron depot range from 1 to 3 ccs every 10 days.

Testosterone is a powerful hormone with notably prominent side effects. Much of which stem from the fact that testosterone exhibits a high tendency to convert into estrogen. Related side effects may therefore become a problem during a cycle. For starters, water retention can become quite noticeable. This can produce a clear loss of muscle definition, as subcutaneous fluids begin to build. The storage of excess body fat may further reduce the visibility of muscle features, another common problem with aromatizing steroids. The excess estrogen level during/after your cycle also has the potential to lead up to gynecomastia. Adding an ancillary drug like Nolvadex and/or Proviron is therefore advisable to those with a known sensitivity to this side effect. As discussed throughout this book, the antiaromatase Arimidex is a much better choice. The expense of this drug unfortunately stops its use from becoming a widespread practice however. It is believed that the use of an antiestrogen can slightly lower the anabolic effect of most androgen cycles (estrogen and water weight are often thought to facilitate strength and muscle gain), so one might want to see if such drugs are actually necessary before committing to use. A little puffiness under the nipple is a sign that gynecomastia is developing. If this is left to further develop into pronounced swelling, soreness and the growth of small lumps under the nipples, some form of action should be taken immediately to treat it (obviously quitting the drug or adding ancillaries).

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Deca Durabolin is the Organon brand name for nandrolone decanoate. World wide Deca is one of the most popular injectable steroids. It's popularity is likely due to the fact that Deca exhibits significant anabolic effects with minimal androgenic side effects. Considered by many the best overall steroid for a man to use (side effects vs. results) Deca is most commonly injected once per week at a dosage of 200-400mg. With this amount, estrogen conversion is slight so gyno is usually not a problem. Also uncommon are problems with liver enzymes, blood pressure or cholesterol levels. At higher dosages, side effects may become increasingly more frequent, but this is still a very well tolerated drug. It should also be noted that in HIV studies, Deca has been shown not only to be effective at safely bringing up the lean bodyweight of patient but also to be beneficial to the immune system. For bodybuilding, Deca can effectively be incorporated in both mass and cutting cycles. One major drawback to Deca is that it can be detected in a drug screen for as long as a year after use. Unfortunately for many competitive athletes, this makes Deca and other nandrolone products off limits.

Deca durabolin is considered to be the most popular of all steroids. It is an oil based injectable that comes in 100 mg/cc containers. It produces very few side effects. Deca durabolin is easy on the liver and promotes good size and strength gains while reducing body fat. Deca only aromatizes (converts to estrogen) in extreme dosages. It is highly anabolic but only moderately androgenic. Deca durabolin does shut down natural testosterone production, but it is not extreme. Gains will minimally dissipate, if at all, after the cycling period if workouts are kept intense. By the way, nandrolone decanoate is also the most counterfeited drug on the black market. Comes in 50, 100 and 200 mg per cc strengths. It seems to be the best of injectables for the cost. Usual dose is 200 mg per week with highs ranging 200 mg a day. The average duration is about 2 to 4 month. There are very few side effects. Blood clotting time is increased so that some people may experience bloody noses when they are dehydrated. Deca durabolin is generally considered by athletes and sports medicine physicians to be the safest and most effective injectable anabolic steroid. Nandrolone decanoate is mildly androgenic and is becoming increasingly popular with women bodybuilders. Although side effects similar to those of other steroids have been reported, the effects are relatively uncommon when compared to other forms of steroids. Nandrolone does not effect the immune system, unlike testosterone! It will not damage connective tissue, i.e. elbows, knees (Big problem amongst heavy steroid users). It does not aromatize easily. Gives the body a lean hard look. Deca can be detected in the body a year after discontinued use.

HCG is provided as a glycoprotein powder to be diluted with water, and acts in the body like LH, stimulating the testes to produce testosterone even when natural LH is not present or is deficient. It therefore is useful for maintaining testosterone production and/or testicle size during a steroid cycle. Use of this drug in the taper is rather counterproductive, since the resulting increased testosterone production is itself inhibitory to the hypothalamus and pituitary, delaying recovery. Thus, if this drug is used, it is preferably used during the cycle itself. A daily amount of 500 IU is generally sufficient, and in my opinion usage should not exceed 1000 IU per day.

Daily administration is superior to less frequent administration.

Doses over 1000 IU are noted for their tendency to cause or aggravate gynecomastia, and also act to desensitize the testicles to LH.

HCG may be injected intramuscularly, subcutaneously, or in a shallow injection about 1/4" deep with the needle going straight in. A 29 gauge insulin needle is recommended. Injection speed should be slow.

HCG, or Human chorionic gonadotropin , which is derived from the urine of pregnant women, is an injectable drug available commercially in the United States as well as many other countries. Pregnyl , made by Organon, and Profasi, made by Serono, are FDA approved for the treatment of undescended testicles in very young boys, hypogonadism (underproduction of testosterone) and as a fertility drug used to aid in inducing ovulation in women. Among athletes, HCG is used to stimulate natural testosterone production during or after a steroid cycle which has caused natural levels to be reduced. Stopping a steroid cycle abruptly, especially when endogenous androgens are absent, can cause a rapid loss in the athlete's newly acquired muscle. When HCG is used to stimulate natural production, a notably pronounced crash may be avoided. HCG is always packaged in 2 different vials,one with a powder and the other with a sterile solvent. These vials need to be mixed before injecting, and refrigerated should any be left for later use.

While it has been claimed that Clomid "stimulates" production of LH and therefore of testosterone, in fact Clomid's activity is achieved not by stimulation of the hypothalamus and pituitary, but by blocking their inhibition by estrogen.
Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist - the cofactor used in that tissue cannot bind and so the receptor remains inactive - and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind.

Clomid is an effective antagonist in the hypothalamus and in breast tissue. It is an effective agonist in bone tissue, and for improving blood cholesterol.

Clomid also has the property of reducing the adverse effect of exercise-induced damage of muscle tissue. This is very significant for endurance athletes but is not very significant, if at all significant, with reasonable weight training. Clomid does not perceptibly affect gains of the weight trainer either favorably or adversely in my experience.

Women and Clomid
The drug seems to have estrogenic effects on mood, which can be beneficial (improving relationships with women by improving empathy) or can yield depression or PMS-like symptoms, but for most users there is no significant effect either way.
The claim that duration of intake should not exceed 10-14 days is incorrect. Clinical studies with male patients have been for periods of a year or longer. This error probably originates from the fact that, for use in women, due to the menstrual cycle there would obviously be no point in trying to stimulate ovulation all four weeks of the month. Thus, use in women is limited to 10-14 days. That limitation is not because of toxicity.
Clomid is in fact useful throughout a cycle if aromatizable drugs are being used. We do think however that to be conservative, one should use it no more than 2/3 of the time throughout the year or a little less.

Clomid is the anti-estrogen of choice for improving recovery of natural testosterone production after a cycle, improving testosterone production of endurance athletes, and is also effective in reducing risk of gynecomastia during a cycle employing aromatizable steroids.